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There's a lot of diseases that don't have good treatments

It's not a flaw in the molecule

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Abbreviations ACE: Angiotensin converting enzyme ADA: American Diabetes Association AT: As treated ATC: Anatomic therapeutic classification BI: Basal insulin CI: Confidence interval CKD: Chronic kidney disease CVD: Cardiovascular disease DPP-4i: Dipeptidyl peptidase-4 inhibitors EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate GLP-1RA: Glucagon-like peptide 1 receptor agonist HDL: High density lipoprotein HHF: Hospitalization for heart failure HR: Hazard ratio ICD: International classification of disease IQR: Interquartile range ITT: Intention to treat LDL: Low density lipoprotein MACE: Major adverse cardiovascular events PS: Propensity score PSM: Propensity score matching rHIE: Regional Health Information Exchange SD: Standard deviation SGLT2i: Sodium glucose co-transporter 2 inhibitors SMD: Standardized mean difference T2D: Type 2 diabetes TIA: Transient ischemic attack References Holman RR, Farmer AJ, Davies MJ, Levy JC, Darbyshire JL, Keenan JF, Paul SK

however, LEAD-6 was open-label and the insulin glargine arm in LEAD-5 was open-label since the basal insulin dose was individually titrated